In response to pain, what substance does the brain signal for release?

When the body experiences pain, the brain responds by signaling the release of endorphins. Endorphins are natural painkillers produced by the central nervous system and the pituitary gland. They function by binding to the same receptors that opioids do, which helps to diminish the perception of pain and promote a sense of well-being. This mechanism is often referred to as the body's natural pain relief system, and it can be triggered by activities such as exercise, stress, or injury.

Endorphins play a significant role in pain management, particularly in situations where quick relief is needed, thereby also influencing emotional responses to pain. Their release can create feelings of euphoria, sometimes referred to as "runner's high," which further aids in coping with physical discomfort. This is why endorphins are considered the primary substances the brain signals for release in response to pain.